Usually Mondays are the worst. But, not today!! It's SFN!!!
microRNA (miRNA) are short strands of RNA that modulate protein expression. To give you an analogy if proteins are lights in a room, miRNA are the dimmer switch. They don't turn the light on or off, but they help ensure that the light isn't too bright, or too dim.
Here were the highlights of today's events ---
Morning session
1. Minano-Molina (C45) - Found that miR-92-3p, miR-181c-5p, miR-210-3p modulation in Alzheimer's transgenic mice.
2. Edler (C20) - Abeta and tau pathology increases with age in chimpanzees. Studies in primates are becoming rare - for ethical reasons. This study was done with primate brains donated by zoos and research institutions.
3. Bicca (C20) - TRPA1 levels in AD mice are changed - possibly via a response to oxidative stress.
4. DeVito (Z26) - This was my favorite poster of the day. 142-3p involvement in a mouse model of Multiple Sclerosis. They found that 142-3p knockout mice show reduced symptoms associated with the mouse model of MS. The target for this miRNA was the mRNA coding for GLAST (glutamate aspartate transporter). They also found that anti-miR-132 - administered via an osmotic mini pump) help reduce symptoms in the MS mouse. I enjoyed that their group covered the miRNA work from basic, in vitro predictions, all the way to in vivo administration of the miRNA.
Lunch -
None. Not happy about it. Still.
Afternoon session
I presented my poster all afternoon. It was D25 - microRNA298 - a dual regulator of proteins involved in Alzheimer's Disease.
SFN Banter
Met some people I have been interacting with on twitter. Remembered that I am incredibly socially awkward in large groups. Also, very jealous of those people who are able to walk up to strangers and engage them in conversation. You know - extroverts.
What did you enjoy about your Monday at SFN?
What did you enjoy about your Monday at SFN?
